| Sun 28-Nov-2021 |
|---|
| 13:00 | Hashtag United Women | 0‑1 | AFC Wimbledon Women | |
| 13:00 | Hull City W | 1‑2 | Liverpool Feds Women | |
| 13:00 | Ilminster Town W | 0‑7 | Southampton Women | |
| 13:00 | Long Eaton United W | 6‑0 | Netherton United | |
| 13:00 | Plymouth Women | 4‑2 | St Austell W | |
| 13:00 | Salford City W | 0‑4 | Newcastle Women | |
| 13:00 | West Brom Women | 4‑1 | Lincoln United Women | |
| Sun 14-Nov-2021 |
|---|
| 15:00 | Solihull Moors W | 0‑3 | Loughborough W | |
| 15:00 | Steyning Town | 0‑3 | Kent | |
| 14:30 | Abingdon United W | 0‑3 | Southampton Women | |
| 14:30 | Fulham W | 0‑3 | Oxford Utd Women | |
| 14:00 | Abingdon Town W | 1‑4 | Gillingham Women | |
| 14:00 | Billericay Town Women | 5‑1 | Luton Women | |
| 14:00 | Bournemouth Sports Ladies | ‑2 | Bournemouth W | |
| 14:00 | Burton Albion W | 0‑4 | Lincoln City Women | |
