| Sun 14-Nov-2021 |
|---|
| 13:30 | Wymondham Town | 0‑2 | Norwich Women | |
| 13:15 | QPR Women | 11‑0 | Bromley W | |
| 13:00 | AFC Telford United W | 0‑4 | Leafield Athletic | |
| 13:00 | Ascot United W | 0‑4 | Chichester & Selsey W | |
| 13:00 | Blackburn Community | 0‑1 | Hull City W | |
| 13:00 | Cheltenham Town W | 4‑0 | Liskeard Athletic | |
| 13:00 | Chesham United W | 3‑2 | Cambridge United W | |
| 13:00 | Crewe W | 0‑5 | West Brom Women | |
| 13:00 | Exeter City W | 3‑1 | Cardiff Women | |
| 13:00 | Hartlepool W | 0‑4 | Leeds Women | |
| 13:00 | Hashtag United Women | 17‑0 | Southend Utd Community | |
| 13:00 | Herne Bay W | 1‑8 | Actonians W | |
| 13:00 | Huddersfield Women | 20‑0 | Sir Tom Finney | |
| 13:00 | Ilminster Town W | 3‑0 | Sherborne Town W | |
| 13:00 | Keynsham Town W | 3‑5 | Plymouth Women | |
